No, LabSand does not change any of the properties of the urine sample collected. Extensive studies have been conducted and there is no chemical reaction between the hydrophobic sand and any of the urine that beads up on top of it. In addition, several well-known veterinarians and research facilities have conducted their own studies and have submitted multiple samples to commercial laboratories. All urinalysis results were identical between their invasive collection methods and LabSand. Click here to view a validation study that provides detailed urinalysis information and photos.