Harvard Pump PHD Ultra infuse/withdraw syringe pump (703006)

Harvard Apparatus introduces the next generation of syringe pumps, the PHD ULTRA™ for the most demanding applications.

Since 1901 Harvard Apparatus has been supporting bioresearch fluidics requirements with the culmination being the introduction of the first commercial syringe pump for bioresearch in 1956. Since 1956, over 70,000 satisfied syringe pump users around the world have made Harvard Apparatus syringe pumps the worlds #1 choice.

The PHD ULTRA™ Syringe Pump series is a family of high-accuracy, microliter- and milliliter-compatible pumps designed for versatile technical use including mass spectroscopy, calibration, drug and nutritional infusions, microdialysis, dispensing, chromatography and LC/HPLC.

Highest Accuracy and Precision
The PHD ULTRA™ syringe pump family has a fluidics drive mechanism which assures ease of use and high performance, for smoother, more accurate flow rates than any other syringe pump. Flow rates are accurate within 0.25% and reproducibility within 0.05%. A microprocessor-controlled, small step angle stepping motor drives a lead screw and pusher block. Advanced micro-stepping techniques are employed to further reduce the step angle to eliminate flow pulsation.

Advanced Programming Features:
• Flow Programming – Change the flow with time, volume or a triggered event as many times as you like
• Bolus – Inject a drug (or drugs) in a high quantity at once. The bolus injection can be made in time or volume.
• Concentration Delivery – Calibrate flow in concentration units of mg/kg easily so flow is calibrated to concentration of drug and animal weight.
• Gradients
• % ratio – up to three solvents
• I/O — dedicated and user defined I/O
• Pulsed Flow- so you can program the pulse easily

Widest Flow Rate Range
This pump is engineered to provide flow accuracy within 0.25% and reproducibility within 0.05%. Single or multi syringes from 0.5 µl to 140 ml pump at a range of 0.0001 µl/hr to 216 ml/min.

Maximum Experimental Versatility
The PHD ULTRA™ features true Multi-Pump Operation. The pump can be oriented vertically or horizontally for optimum experimental connectivity. This pump comes standard to hold 2 syringes, but can be purchase with 3 other syringe racks: 6 to 10 syringe rack, 4 x 140ml syringe rack and 4 x microliter syringe rack.

Easy-to-Use Interface
The PHD ULTRA™ color LCD touch screen graphic interface is divided into three basic areas: Operations Display, Message Area, and Navigation. This configuration allows you to easily move through all menu selections and data entry by gently touching the onscreen buttons with a finger or the tip of a soft, non-sharp object such as a pencil eraser.

The Methods Main or Quick Start screens are the primary home for the applications. From those screens you access all the commands needed to operate the PHD ULTRA™, as well as the main system settings.

The Message Area of the touch screen is used to display helpful instructions for the currently displayed screen. It is also used to display error or warning messages to indicate problem conditions in a Method or error conditions during pump operation.

The software is organized into three main Navigational branches, the quick start operations, preloaded/user-defined Methods, and systems settings. You can control operations directly with the touch screen or remotely from an independent computer or device via the external I/O interface.

Program Description
To operate the PHD ULTRA™, the user defines all the required parameters for infusing or withdrawing liquids through a Pump Control Method. The basic operation is a simple 4-step procedure:

1. Select a method
2. Enter operating parameters
3. Preview your method
4. Run your method

Applications
• Animal Infusions or Withdrawals – The PHD ULTRA™ will control the delivery of varying % of nutrients or drugs infused into animals, flush lines using catheters, needles, cannulae or microdialysis.
• Proportioning and Delivering of Mixtures – Mixing gradients or proportions with independent control of two liquids.
• Aerosol for Coating – The pump at high pressure can create an aerosol for the delivery of coating materials such as pharmaceutical tablets and aerosol studies.
• Delivery to Mass Spectroscopy – The delivery of fluids to the MS for calibration, matrix addition or ESI sample.
• Compensating Flows – The continuous infusion and simultaneous withdrawal of liquids for cell cultures or perfusion chambers.
• Dispensers/Injectors — Adhesives, Cell injection, MRI Dyes, Activators/Enzymes, Flow injection, Microreaction vessels, or Stereotaxic delivery.

Advanced GLP Documentation Features:
• Experiment parameter download information to PC
• Alpha/numeric capability

Pump Models
The PHD ULTRA™ Syringe Pump is available in three configurations designed for different operating environments and varying degrees of operational flexibility.

1. Infuse Only: This model supports infusion operations at user-definable flow rates and with selectable target volume or time values to control the total infusion volume. The entry-level Infuse Only model does not include programmable, user-defined methods.

2. Infuse/Withdraw: This model supports infusion and withdraw operations at user-definable flow rates and with selectable target volumes or time values to control the total volume pumped for both the infusion and withdraw portions of a procedure. This model provides access to many of the advanced method programming options of the PHD ULTRA™, but only supports a single stored method.

3. Infuse/Withdraw Programmable: This model supports both infusion and withdraw operations and can use both simplified pumping profiles or the more advanced pump profiles and I/O settings that permit interactions with external devices. In addition to supporting all of the advanced programming tools available on the PHD ULTRA™, this model also allows users to create and store multiple user-defined methods on the pump.

Syringe Racks
The PHD ULTRA™ is offered with a variety of syringe racks to meet your specific application.

Specifications	70-3006 HA3000W	70-3007 HA3000P	70-3008	70-3009
Accuracy	±0.25%	±0.25%	±0.25%	±0.25%
Classification	Class I	Class I	Class I	Class I
Dimensions Control Box LxDxH in cm	12.0 x 8.5 x 7.25 (30.48 x 21.59 x 18.42)	12.0 x 8.5 x 7.25 (30.48 x 21.59 x 18.42)	12.0 x 8.5 x 7.25 (30.48 x 21.59 x 18.42)	12.0 x 8.5 x 7.25 (30.48 x 21.59 x 18.42)
Display	4.3″ WQVGA TFT Color Display with Touchpad	4.3″ WQVGA TFT Color Display with Touchpad	4.3″ WQVGA TFT Color Display with Touchpad	4.3″ WQVGA TFT Color Display with Touchpad
Drive Motor	0.9° Stepper Motor	0.9° Stepper Motor	0.9° Stepper Motor	0.9° Stepper Motor
Environmental Humidity	20% to 80% RH, non condensing	20% to 80% RH, non condensing	20% to 80% RH, non condensing	20% to 80% RH, non condensing
Environmental Operating Temperature English	40°F to 104°F*	40°F to 104°F*	40°F to 104°F*	40°F to 104°F*
Environmental Operating Temperature Metric	4°C to 40°C*	4°C to 40°C*	4°C to 40°C*	4°C to 40°C*
Environmental Storage Temperatue English	14°F to 158°F	14°F to 158°F	14°F to 158°F	14°F to 158°F
Environmental Storage Temperatue Metric	-10°C to 70°C	-10°C to 70°C	-10°C to 70°C	-10°C to 70°C
Flow Rate Maximum	216 ml/min using 140 ml syringe	216 ml/min using 140 ml syringe	216 ml/min using 140 ml syringe	216 ml/min using 140 ml syringe
Flow Rate Minimum	1.56 pl/min using 0.5 µl syringe	1.56 pl/min using 0.5 µl syringe	1.56 pl/min using 0.5 µl syringe	1.56 pl/min using 0.5 µl syringe
I/O & TTL Connectors	15 pin D-Sub Connector	15 pin D-Sub Connector	15 pin D-Sub Connector	15 pin D-Sub Connector
Input Power	50 W, 0.5 A fuse	50 W, 0.5 A fuse	50 W, 0.5 A fuse	50 W, 0.5 A fuse
Installation Category	II	II	II	II
Max Linear Force	75 lbs @ 100% Force Selection	75 lbs @ 100% Force Selection	75 lbs @ 100% Force Selection	75 lbs @ 100% Force Selection
Mode of Operation	Continuous	Continuous	Continuous	Continuous
Motor Drive Control	Microprocessor with 1/16 microstepping	Microprocessor with 1/16 microstepping	Microprocessor with 1/16 microstepping	Microprocessor with 1/16 microstepping
Net Weight English	10 lb	10 lb	10 lb	10 lb
Net Weight Metric	4.5 kg	4.5 kg	4.5 kg	4.5 kg
No of Syringes	2	2	4	4
Non Volatile Memory	Storage of all settings	Storage of all settings	Storage of all settings	Storage of all settings
Number of Microsteps per one rev of Lead Screw	12,800	12,800	12,800	12,800
Pollution Degree	1	1	1	1
Pump Configuration	Standard	Standard	Standard	Standard
Pump Function	Infuse/Withdraw	Infuse/Withdraw, Programmable	Infuse/Withdraw	Infuse/Withdraw, Programmable
Pusher Travel Rate Maximum	190.8 mm/min	190.8 mm/min	190.8 mm/min	190.8 mm/min
Pusher Travel Rate Minimum	0.18 µm/min	0.18 µm/min	0.18 µm/min	0.18 µm/min
Regulatory Certifications	CE, UL, CSA, CB Scheme, EU RoHS	CE, UL, CSA, CB Scheme, EU RoHS	CE, UL, CSA, CB Scheme, EU RoHS	CE, UL, CSA, CB Scheme, EU RoHS
Reproducibility	±0.05%	±0.05%	±0.05%	±0.05%
Step Rate Maximum	26 µsec/µstep	26 µsec/µstep	26 µsec/µstep	26 µsec/µstep
Step Rate Minimum	27.5 sec/µstep	27.5 sec/µstep	27.5 sec/µstep	27.5 sec/µstep
Syringe Rack Type	Standard Rack	Standard Rack	Push/Pull Syringe Rack	Push/Pull Syringe Rack
Syringe Size Maximum	140 ml	140 ml	140 ml	140 ml
Syringe Size Minimum	0.5 µl	0.5 µl	0.5 µl	0.5 µl
USB Connectors	Type B	Type B	Type B	Type B
Voltage Range	100-240 VAC, 50/60 Hz	100-240 VAC, 50/60 Hz	100-240 VAC, 50/60 Hz	100-240 VAC, 50/60 Hz
RS 232 Connectors	9 pin D-Sub Connector	9 pin D-Sub Connector	9 pin D-Sub Connector	9 pin D-Sub Connector